Uric acid clearance in patients with gout and normal subjects.

[Uric acid clearance in normal and gouty subjects].

substrates and products have no effect. Fractionation of normal erythrocytes by hypotonic lysis reveals a decline in the specific activity of A-PRT as the red cells age. In patients with the Lesch-Nyhan syndrome, the decline in A-PRT activity with ageing of cells is much less marked. Furthermore, the concentrations of free PRPP are as much as 10-fold elevated in the erythrocytes of these childr...

Acute gout attack with normal serum uric acid levels.

AIM The paper aims to determine the prevalence of clinical cases with acute gout attacks and normal serum uric acid levels. MATERIAL AND METHODS This retrospective study was conducted between October, 2013 and June, 2014 in 30 patients diagnosed with acute gout attack admitted to the 1st Clinic of Rheumatology of Iasi. The diagnosis was based on clinical manifestations and positive response t...

Uric acid excretion in the relatives of patients with gout.

The patients all had a diagnosis of primary gout, i.e. they had a characteristic history of acute episodic arthritis with a serum uric acid level above 6 mg./100 ml. and no evident underlying cause for hyperuricaemia. The investigation was carried out before treatment with uratelowering drugs was started. The nature of the study was explained to them and to as many as possible of their adult fi...

Uric acid production in gout.

Evaluation of Serum Uric Acid and Glutathione Levels in Diabetic Patients and Healthy Subjects

Objective: It is well known that diabetes is one of the main health challenges. According to the evidence presented in recent years by investigators, serum uric acid has emerged as a possible risk factor for diabetes mellitus. The aim of the present study was to compare the mean serum uric acid and the antioxidant activity of glutathione levels in patients with diabetes and the control group. ...